emeritus professor, pediatrician
Genes, age and gender can influence, in addition to the daily routine.
This is a discussion post. Opinions in the text are the responsibility of the writer.
Vaccines, like all medicines, are associated with the risk of serious side effects. Several of them are indisputable: anaphylactic shock in highly allergic people, injuries from dirty vaccine, and inappropriate use of the vaccine.
Other than the 2009 swine flu vaccine, serious side effects from vaccines are very rare. At that time, several hundred people in many countries, especially children and young people, contracted the serious disease of narcolepsy.
The side effects of vaccines can have both genetic and immunological causes.
In the case of infections or vaccines, different people tend to react differently. Some become very ill, with a high fever, decreased muscle strength, and dizziness. Others have a much milder course of the disease.
Recent research have shown This may be due to variations in the genes that determine how the body responds to such acute stimulation of the immune system. After the swine flu vaccine, only people with tissue type HLADQ6 developed narcolepsy.
Furthermore, there is good evidence that the immunological conditions of the vaccine itself are important. This association is best documented for side effects that also occur such as so-called autoimmune diseases, such as ITP (immune thrombocytopenic purpura) and narcolepsy.
For some vaccines, the antibodies that are formed will not only target the infectious agent. They will also bind to platelets (platelets), which are important for maintaining normal blood clotting, and destroy them with thrombopenia (low platelets) and bleeding as a result.
I and study Out of more than one million children aged 0 to 18 years, it was concluded that more than 70% of ITP cases were caused by such a cross-reaction after vaccination in the childhood vaccination program.
Also the similar WHITE side effect (vaccine-induced thrombopenic thrombosis) after Astra Zeneca vaccine, with bleeding, thrombosis, stroke and death, probably due to a cross-reaction, as Norwegian researchers have shown.
Narcolepsy after the swine flu vaccine is probably also caused by such a cross-reaction. The vaccine response targeted not only the virus, but also the brain cells that regulate sleep and wakefulness, and destroyed them.
After the swine flu vaccine, only a few people with the HLADQ6 tissue type developed narcolepsy, although this tissue type is found in between 20 and 30 percent of the population. Therefore, these must have had another vulnerability in addition to genetics.
Most cases of narcolepsy occurred in children and adolescents. Therefore, vulnerability can be linked to different phases of growth, development and hormonal maturation of the individual.
Similar conditions has also been found for ITP, which appear to occur with different frequencies in different age groups after different vaccines.
Adverse reaction statistics from the Norwegian Medicines Agency also show large gender and age differences in the frequency of adverse reactions after coronary vaccines. So far (as of September 7 of this year) a total of 31,180 adverse reactions have been reported, of which 16,865 (54%) have been treated.
Of these, 2,634 are classified as severe and have occurred twice as often in women as in men, 1,756 and 878, respectively.
Regarding the side effect of myocarditis (inflammation of the heart muscle), 49 cases have been reported, with a great predominance in young men.
In addition to genetic and immunological conditions, both age and gender (i.e. development and hormones) can explain why side effects are distributed differently in the population.
How common are serious side effects from vaccines?
Figures from USA shows that serious side effects in the childhood vaccination program occur as rarely as a few per. millions of doses of vaccines established.
There are not good numbers for the swine flu vaccine, but there are probably 100 to 200 serious side effects per day. million vaccines.
In the case of coronary vaccines, serious side effects appear to be more common. According to reports from FHI and the Norwegian Medicines Agency, there are 376 cases per million doses and twice as many in women as in men.
Inflammation of the heart in young men (12-39 years) also occurs relatively frequently, with approx. 68 boxes for millions of vaccines.
These are high numbers for serious side effects. But authorities consider them acceptable based on the goal of a fully vaccinated population.
Sick people should not be vaccinated
Therefore, the side effects of vaccines are determined by a number of biological conditions, such as genetics, immunology, age, gender, and others.
In addition, the vulnerability of the individual is likely to be affected by daily form as well.
In the childhood immunization program, it is a general instruction that children who are ill or have a fever of unknown cause should not be vaccinated until a week or two after they have recovered.
These symptoms may indicate that the child has an infection that also stimulates the immune system. So an extra boost from a vaccine can be unfortunate.
Many childhood vaccines contain several individual vaccines (MMR, Triple, etc.).
If a child reacts strongly to such a vaccine, it is common, as a precautionary principle, to skip one or more of these individual vaccines in the next round, because the immune boost may have become too strong. Instead, the vaccine is given as a single vaccine at a later date.
The same precautionary principle should also apply to adults.