Human blood plasma biomarkers can estimate a person's chronological or biological age, which may differ from their actual age.
Researchers found that molecular alterations occur naturally with age.
Blood plasma contains proteins, metabolites, and nucleic acids, which can be analyzed.
Scientists have created models and algorithms to determine a person's age from their blood plasma profile by studying these molecules' amounts and patterns.
DNA methylation analysis is frequent. DNA methylation changes gene expression chemically.
Researchers can develop an age-related DNA methylation profile by studying CpG sites.
Algorithms can determine someone's age by comparing their methylation profile to a reference dataset.
Certain proteins and metabolites also correlate with age. Inflammatory markers and oxidative stress-related molecules rise with age, but hormones and growth factors fall.
These blood plasma indicators can predict age by comparing them to reference ranges.